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Spermidine is a natural low molecular weight polyamine widely distributed in various organisms.
It has a high capacity to promote the reparative effect of periodontal, bone and dental tissue damaged by the erosive effects of periodontitis.
The structural feature is crucial for its functions, which include DNA stabilization, promotion of cell growth, and induction of autophagya.
CPQ Dentistry (2019) 1:4 Research Article
Spermidine Associated to Non-Surgical Treatment of Periodontal
Disease: Split Mouth Randomized Controlled Clinical Trial.
Daniela Carmagnola · Carlo Angelo Ghisalberti · Gaia Pellegrini · Lucrezia Cinquanta · Marilisa Toma & Claudia Dellavia
Ubigel activates the mechanistic action of the connective tissue cells by stimulating the exchange and production of proteins that promote cellular activities for the well-being of the periodontist without altering its morphology and inducing the healing of the gums from the periodontitis.
Clinical Oral Investigations (2024) 28:537
Treatment of peri-implant mucositis using spermidine and calcium chloride as local adjunctive delivery to non-surgical mechanical debridement: a double-blind randomized controlled clinical trial.
Vincenzo Iorio-Siciliano · Dario Marasca · Leopoldo Mauriello · Enzo Vaia · Stefan-Ioan Stratul · Luca Ramaglia